徐燕意

环境污染物的毒性机制与跨代效应研究

1. 环境卫生学/环境卫生学实验
2. 环境医学综合实验课
3. 预防医学导论
4. 环境与健康
5. Air pollution, climate change and health
6. 多组学与健康

2011-2015👩‍🎓，美国俄亥俄州立大学(The Ohio State University)，博士生，导师：Peter Anderson教授，Jianjun Guan教授

2015-2016，美国俄亥俄州立大学(The Ohio State University)，博士后研究员，合作导师：Peter Anderson教授，Jianjun Guan教授

2016-2017⌛️：美国阿克隆大学(The University of Akron)，博士后研究员👩‍💻，合作导师：Matthew Becker教授

2017-至今：杏鑫平台🤦🏽‍♂️，环境卫生教研室

1. 2019-至今   中国环境诱变剂学会致突变专业委员会青年委员会    委员
2. 2020-至今   上海市环境科学学会化学品污染物排放毒性鉴定与风险防控专业委员会   委员
3. 2020-至今    中国环境科学学会臭氧污染控制专业委员会   委员
4. 2021-至今   上海市预防医学会环境卫生专委会   秘书及委员
5. 2021-至今   上海市预防医学会卫生毒理专委会   委员
6. 2023-至今   《Eco-Environment & Health》青年编委

2017,  上海市浦江人才

2023👩🏽‍💼，上海市医苑新星

Publications（Selected）: 

1. Yuanting Xie et al., Cholinergic anti-inflammatory pathway mediates diesel exhaust PM2.5-induced pulmonary and systemic inflammation, Journal of Hazardous Materials, 2023.
2. Shimin Tao et al., Maternal exposure to ambient PM2.5 perturbs the metabolic homeostasis of maternal serum and placenta in mice, Environmental Research, 2022.
3. Renzhen Peng et al., Deficiency of interleukin-6 receptor ameliorates PM2.5 exposure-induced pulmonary dysfunction and inflammation but not abnormalities in glucose homeostasis, Ecotoxicology and Environmetal Safety, 2022.
4. Minjie Chen et al., Paternal exposure to PM2.5 progrmas offspring's energy homeostasis, Environmental Science & Technology, 2021.
5. Shimin Tao et al., Exposure to different fractions of diesel exhaust PM2.5 induces different levels of pulmonary inflammation and acute phase response, Ecotoxicology and Environmetal Safety, 2021.
6. Bin Pan et al., Hypothalamic-pituitary-adrenal axis mediates ambient PM2.5 exposure-induced pulmonary inflammation, Ecotoxicology and Environmetal Safety, 2020.
7. Yanyi Xu et al., Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model, Particle and Fibre Toxicology, 2019.
8. Yanyi Xu et al., Metabolomics analysis of a mouse model for chronic exposure to ambient PM2.5, Environmental Pollution, 2019.
9. Wanjun Wang et al., Exposure to concentrated ambient PM2.5 alters the composition of gut microbiota in a murine model, Particle and Fibre Toxicology, 2018.
10. Minjie Chen et al., Concentrated ambient PM2.5-induced inflammation and endothelial dysfunction in a murine model of neural IKK2 deficiency, Environmental Health Perspectives, 2018.
11. Minjie Chen et al.,Programming of mouse obesity by maternal exposure to concentrated ambient fine particles, Particle and Fibre Toxicology, 2017.01.02, 14(1): 20.
12. Ziying Hu et al.,Inactivation of TNF/LT locus alters metabolic response to concentrated ambient PM2.5, Toxicology , 2017.9.1, 390: 100~108.
13. Minjie Chen et al., Prenatal and postnatal mothering by diesel exhaust PM2.5-exposed dams differentially program mouse energy metabolism, Particle and Fibre Toxicology, 2017.06.06, 14(1): 3.
14. Shan Li et al,Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies, Biomaterials, 2017.06.28, 141: 176~187.

自2017年以来，作为导师组成员指导博士生7名（4名在读，3名已毕业），作为责任导师指导研究生11名（4名在读，7名已毕业）。

招收研究生🐎，请有兴趣的同学通过邮件与我联系。

报考方向👮🏽🦄：

学术学位硕士生：劳动卫生与环境卫生学

专业学位硕士生🙆🏻：公共卫生

YANYI XU                    

No 130 Dong'an Rd, Shanghai, China, 200032.

Email: yanyi_xu@fudan.edu.cn 

H-index: 21      i10-index: 28     Citations: 1189 (By 2023.08.05)

RESEARCH AREA

• Environmental toxicology
• Toxicology of fine and ultrafine particles
• In vivo and in vitro toxicological models
• Cross-generational effect

WORK EXPERIENCE

2020.12-Now   Associate Professor, Fudan University

2017.01-2020.12 Associate Research Fellow, Fudan University

2016.03-2016.12 Postdoctoral Researcher, University of Akron, USA

• Collaborator: Prof. Matthew L. Becker

2015.08-2016.03 Postdoctoral Researcher, The Ohio State University, USA

• Collaborators: Prof. Jianjun Guan, Prof. Peter M. Anderson

EDUCATION

2011.09-2015.08 The Ohio State University, Columbus, USA

              Ph.D. in Materials Toxicology

• Advisors: Prof. Jianjun Guan, Prof. Peter M. Anderson

2007.08-2011.07 Harbin Institute of Technology, Harbin, China

              B.S. with honors in Composite Materials and Engineering

• Advisor: Prof. Jinsong Leng

POSITIONS

• 2023-Now, Committee Member of Young Editorial Board, Eco Environment & Health
• 2021-Now, Committee Member & Secretary, Shanghai Preventive Medicine Association-Commission of Environmental Health
• 2021-Now, Committee Member, Shanghai Preventive Medicine Association-Commission of Hygiene Toxicology
• 2020-Now, Committee Member, Chinese Society of Environmental Sciences-Commission for Ozone Control
• 2020-Now, Committee Member, Shanghai Society of Environmental Science-Commission for the Identification and Risk Control of Chemical Pollutant
• 2019-Now, Committee Member, Chinese Environmental Mutagen Society

PUBLICATIONS (SELECTED)

1. Xie, S. Tao, B. Pan, W. Yang, W. Shao, X. Fang, D. Han, J. Li, Y. Zhang, R. Chen, W. Li, Y. Xu, H. Kan. Cholinergic anti-inflammatory pathway mediates diesel exhaust PM2.5-induced pulmonary and systemic inflammation. Journal of Hazardous Materials. 2023;131951. (Co-corresponding Author)
2. Han, R. Chen, H. Kan, Y. Xu. The bio-distribution, clearance pathways, and toxicity mechanisms of ambient ultrafine particles. Eco-Environment & Health. 2023;95-106.  (Corresponding Author)
3. Tao, M. Yang, B. Pan, Y. Wang, F. Tian, D. Han, W. Shao, W. Yang, Y. Xie, X. Fang, M. Xia, J. Hu, H. Kan, W. Li, Y. Xu. Maternal exposure to ambient PM2.5 perturbs the metabolic homeostasis of maternal serum and placenta in mice. Environmental Research. 2023;216:114648. (Co-corresponding Author)
4. Peng, W. Yang, W. Shao, B. Pan, Y. Zhu, Y. Zhang, H. Kan, Y. Xu, Z. Ying. Deficiency of interleukin-6 receptor ameliorates PM2.5 exposure-induced pulmonary dysfunction and inflammation but not abnormalities in glucose homeostasis. Ecotoxicology and Environmental Safety. 2022;247:114253. (Co-corresponding Author)
5. T. Chen, D. Norback, Q. Deng, C. Huang, H. Qian, X. Zhang, Y. Sun, T. Wang, Y. Zhang, B. Li, H. Kan, L. Wei, C. Liu, Xu, Z. Zhao. Maternal exposure to PM2.5/BC during pregnancy predisposes children to allergic rhinitis which varies by regions and exclusive breastfeeding. Environmental International. 2022;107315. (Co-corresponding Author)
6. S. Tao, X. Zhang, F. Tian, B. Pan, R. Peng, Y. Wang, M. Xia, M. Yang, J. Hu, H. Kan, Xu, W. Li. Maternal exposure to ambient PM2.5 causes fetal growth restriction via the inhibition of spiral artery remodeling in mice. Ecotoxicology and Environmental Safety. 2022; 237:113512. (Co-corresponding Author)
7. M. Yang, F. Tian, S. Tao, M. Xia, Y. Wang, J. Hu, B. Pan, Z. Li, R. Peng, H. Kan, Xu, W. Li. Concentrated ambient fine particles exposure affects ovarian follicle development in mice. Ecotoxicology and Environmental Safety. 2022; 231:113178. (Co-corresponding Author)
8. M. Chen, Xu, W. Wang, X. Wang, L. Qiu, S. Chen, H. Kan, Z. Ying. Paternal exposure to PM2.5 programs offspring’s energy homeostasis. Environmental Science & Technology. 2021; 55(9):6097-6106. (Co-first Author)
9. Pan, M. Chen,X. Zhang, S. Liang, X. Qin, L. Qiu, Q. Cao, R. Peng, S. Tao, Z. Li, Y. Zhu, H. Kan, Y. Xu, Z. Ying. Hypothalamic-pituitary-adrenal axis mediates ambient PM2.5 exposure-induced pulmonary inflammation. Ecotoxicology and Environmental Safety. 2021; 208:111464. (Co-corresponding Author)
10. Y. Xu, Z. Li, Y. Liu, B. Pan, R. Peng, W. Shao, W. Yang, M. Chen, H. Kan, Z. Ying, Y. Zhang. Differential roles of water-insoluble and water-soluble fractions of diesel exhaust particles in the development of adverse health effects due to chronic instillation of diesel exhaust particles. Chemical Research in Toxicology. 2021; 34(12):2450-2459. (First Author)
11. Tao, Y. Xu, M. Chen, H. Zhang, X. Huang, Z. Li, B. Pan, R. Peng, Y. Zhu, H. Kan, W. Li, Z. Ying. Exposure to different fractions of diesel exhaust PM2.5 induces different levels of pulmonary inflammation and acute phase response. Ecotoxicology and Environmental Safety. 2021; 210:111871. (Co-first Author)
12. Yang, Y. Xu, H. Pan, F. Tian, Y. Wang, M. Xia, J. Hu, M. Yang, S. Tao, S. Sun, H. Kan, R. Li, Z. Ying, W. Li. Chronic exposure to diesel exhaust particulate matter impairs meiotic progression during spermatogenesis in a mouse model. Ecotoxicology and Environmental Safety. 2020; 202:110881. (Co-first Author)
13. Xu, W. Wang, M. Chen, J. Zhou, X. Huang, S. Tao, B. Pan, Z. Li, X. Xie, W. Li, H. Kan, Z. Ying. Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model. Particle and Fibre Toxicology. 2019;16:1-11. (First Author & Co-corresponding Author)
14. Xu, W. Wang, J. Zhou, M. Chen, X. Huang, Y. Zhu, X. Xie, W. Li, Y. Zhang, H. Kan, Z. Ying. Metabolomics analysis of a mouse model for chronic exposure to ambient PM2.5. Environmental Pollution. 2019; 247:953-963. (First Author)
15. Wang, J. Zhou, M. Chen, X. Huang, X. Xie, W. Li, Q. Cao, H. Kan, Y. Xu, Z. Ying. Exposure to concentrated ambient PM2.5 alters the composition of gut microbiota in a murine model. Particle and Fibre Toxicology. 2018;15:1-13. (Co-corresponding Author)
16. Hu, M. Chen, H. Zhou, A. Tharakan, X. Wang, L. Qiu, S. Liang, X. Qin, Y. Zhang, W. Wang, Y. Xu, Z. Ying. Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5. Toxicology. 2017; 390:100-108. (Co-corresponding Author)
17. Xu,D. Luong, J. Walker, D. Dean, M. Becker. Modification of poly (propylene fumarate)-bioglass composites with peptide conjugates to enhance bioactivity. Biomacromolecules. 2017; 18(10):3168-3177. (First Author)